Scientific Publications

1. Tan, X., Knesha, R., Margolin, W. and CHEN, Y. DNA enzyme generated by a novel single-stranded DNA expression vector inhibits expression of the essential bacterial cell division gene ftsZ, Biochemistry, 43: 1111-1117, 2004.
    
2. McMicken, H., Bates, P. and CHEN, Y.* Antiproliferative activity of G-quartet-containing oligonucleotides generated by a novel single-stranded DNA expression system, Cancer Gene Therapy, 10(12):867-869, 2003.
    
3. CHEN, Y. and McMicken, H. Intracellular production of DNA enzyme by a novel single-stranded DNA expression vector, Gene Therapy, 10:1776-1780, 2003.
    
4. CHEN, Y. , Ji, Y., and Conrad, C. Expression of single-stranded DNA in mammalian cells, Biotechniques, 34:167-171, 2003.
    
5. CHEN, Y. A novel single-stranded DNA (ssDNA) expression vector (Review), Expert Opinion on Biological Therapy, 2:735-740, 2002.
    
6. CHEN, Y. Meeting highlights, 10th International conference on gene therapy of cancer, Expert Opinion on Biological Therapy, 2:443-445, 2002.
    
7. Datta, H., and Glazer, P. Intracelullar generation of single-stranded DNA for chromosomal triplex formation and induced recombination, Nucleic Acid Research, 29:5140-5147, 2001.
    
8. CHEN, Y. , Ji, Y., Roxby, R., and Conrad, C. In vivo expression of single-stranded DNA in mammalian cells with DNA enzyme sequences targeted to c-raf, Antisense & Nucleic Acid Drug Development, 10: 415-422, 2000.
    

Other Publications

1. Xin-Xing Tan and Yin Chen, A Novel Genomic Approach Identifies Bacterial DNA-Dependent RNA Polymerase as the Target of an Antibacterial Oligodeoxynucleotide, RBL1, February 9, 2005
    
2. CHEN, Y. and Tan, X.-X. Oligodeoxynucleotide intervention for prevention and treatment of sepsis, pp.21-23, April 2004.
    
3. CHEN, Y., Novel Technologies for target validation, Genetic Engineering News, 23(11):7-9, 2003.
    
4. 21st Century Medicine: Genetic therapy promises dramatic change from treating symptoms to eliminating the disease, E*Street Journal, December, 2002.
    
5. CHEN, Y., Growth of oligo-based drugs, Genomics & Proteomics, October, 2002.
    
6. A marvel of biochemical engineering means cells can produce DNA enzyme to attach cancer, New Scientist, January, 2001.
    

Conference Presentations

1. CHEN, Y., Ji, Y., and Conrad, C. "Novel intracellular single-stranded DNA expression system: production of c-raf RNA-cleaving DNA enzyme", Keystone Symposia, Gene Therapy 2001: A Gene Odyssey", January 6-11, 2001, Snowbird, Utah;
    
2. CHEN, Y., "Novel intracellular single-stranded DNA expression system: production of c-raf RNA-cleaving DNA enzyme", Tenth International Conference on Gene Therapy of Cancer, December 13-15, 2001, San Diego, California (invited speaker);
    
3. CHEN, Y., and McMicken, H. "Intracellular Production of DNA enzyme by a novel single-stranded DNA expression vector", 5th Annual Meeting of the American Society of Gene Therapy, June 5-9, 2002, Boston, Massachusetts;
    
4. CHEN, Y. "Application of a novel single-stranded DNA expression vector for gene regulation", Eleven International Conference on Gene Therapy of Cancer, December 12-14, 2002, San Diego, California;
    
5. CHEN, Y., and McMicken, H. "Application of novel single-stranded DNA expression vector for gene regulation", Keystone Symposia, Drug Target Validation Gene Suppression, January 17-22, 2003, Tahoe City, California;
    
6. CHEN, Y., Novel Intracellular Single-Stranded DNA Expression System and Its Applications. 3rd Annual Conference: RNA in Drug Development - RNA as Tool and Target, San Diego, CA, November 10-13, 2003 (invited speaker).
    
7. CHEN, Y. et al., "In vivo generation of oligodeoxynucleotides for regulating gene expression". Keystone Symposia, New Advances in Drug Discovery, March 21-26, 2004, Keystone, Colorado.